Cognitive performance of healthy young rats following chronic donepezil administration
Psychopharmacology, ISSN: 0033-3158, Vol: 197, Issue: 4, Page: 661-673
2008
- 18Citations
- 43Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations18
- Citation Indexes18
- 18
- CrossRef11
- Captures43
- Readers43
- 43
- Mentions1
- Blog Mentions1
- Blog1
Most Recent Blog
Cholinergic Potentiation Improves Perceptual-Cognitive Training of Healthy Young Adults in Three Dimensional Multiple Object Tracking
Introduction Moreover, recent evidence shows that stimulation of the neuromodulatory brain systems may potentiate perceptual learning (long-term improvement of perception induced by sensory training; Rokem and Silver, 2010; Kang et al., 2015). It has been shown that the cholinergic system improves the efficiency of cortical processing of visual stimuli. In rats, donepezil (DPZ), the AChEI most uni
Article Description
Rationale: Experimental studies have investigated the effects of chronic donepezil treatment on the behavioral deficits elicited by reduced activity or the loss of cholinergic neurons that occurs in aging or in models of dementia. However, few studies have analyzed the effects of chronic donepezil treatment on the cognitive functions of intact animals. Objectives: The cognitive functions of healthy young rats treated chronically with the acetylcholinesterase inhibitor donepezil were evaluated using a wide behavioral test battery. Results: Chronic treatment with donepezil ameliorated memory functions and explorative strategies, speeded up the acquisition of localizing knowledge, augmented responsiveness to the context, and reduced anxiety levels. However, it did not affect spatial span, modify motivational levels, or influence associative learning. Conclusions: The present findings show the specific profile of donepezil action on cognitive functions in the presence of unaltered cholinergic neurotransmission systems. © 2008 Springer-Verlag.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=41849147112&origin=inward; http://dx.doi.org/10.1007/s00213-008-1084-0; http://www.ncbi.nlm.nih.gov/pubmed/18309476; http://link.springer.com/10.1007/s00213-008-1084-0; https://dx.doi.org/10.1007/s00213-008-1084-0; https://link.springer.com/article/10.1007/s00213-008-1084-0; http://www.springerlink.com/index/10.1007/s00213-008-1084-0; http://www.springerlink.com/index/pdf/10.1007/s00213-008-1084-0
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