Pre-treatment differences and early response monitoring of neoadjuvant chemotherapy in breast cancer patients using magnetic resonance imaging: A systematic review
European Radiology, ISSN: 0938-7994, Vol: 22, Issue: 12, Page: 2607-2616
2012
- 61Citations
- 78Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations61
- Citation Indexes61
- 61
- CrossRef57
- Captures78
- Readers78
- 78
- Mentions1
- News Mentions1
- News1
Most Recent News
Biomarkers Investigation of Neoadjuvant Chemotherapy for Breast Cancer; BINC-B
STUDY INFORMATION OFFICIAL TITLE: The Role of Multimodal Imaging and Circulating Biomarkers in Predicting the Response of Neoadjuvant Chemotherapy for Breast Cancer CURRENT STATUS: Recruiting
Article Description
Objectives: To assess whether magnetic resonance imaging (MRI) can identify pre-treatment differences or monitor early response in breast cancer patients receiving neoadjuvant chemotherapy. Methods: PubMed, Cochrane library, Medline and Embase databases were searched for publications until January 1, 2012. After primary selection, studies were selected based on predefined inclusion/exclusion criteria. Two reviewers assessed study contents using an extraction form. Results: In 15 studies, which were mainly underpowered and of heterogeneous study design, 31 different parameters were studied. Most frequently studied parameters were tumour diameter or volume, K, K, V, and apparent diffusion coefficient (ADC). Other parameters were analysed in only two or less studies. Tumour diameter, volume, and kinetic parameters did not show any pre-treatment differences between responders and non-responders. In two studies, pretreatment differences in ADC were observed between study groups. At early response monitoring significant and nonsignificant changes for all parameters were observed for most of the imaging parameters. Conclusions: Evidence on distinguishing responders and non-responders to neoadjuvant chemotherapy using pretreatment MRI, as well as using MRI for early response monitoring, is weak and based on underpowered study results and heterogeneous study design. Thus, the value of breast MRI for response evaluation has not yet been established. Key Points: • Few well-validated pre-treatment MR parameters exist that identify responders and non-responders. • Eligible studies showed heterogeneous study designs which hampered pooling of data. • Confounders and technical variations of MRI accuracy are not studied adequately. • Value of MRI for response evaluation needs to be established further. © European Society of Radiology 2012.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84870370610&origin=inward; http://dx.doi.org/10.1007/s00330-012-2653-5; http://www.ncbi.nlm.nih.gov/pubmed/22983282; http://link.springer.com/10.1007/s00330-012-2653-5; https://dx.doi.org/10.1007/s00330-012-2653-5; https://link.springer.com/article/10.1007/s00330-012-2653-5
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