Tumor microenvironment: A main actor in the metastasis process
Clinical and Experimental Metastasis, ISSN: 0262-0898, Vol: 29, Issue: 4, Page: 381-395
2012
- 168Citations
- 151Captures
- 1Mentions
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations168
- Citation Indexes167
- 167
- CrossRef83
- Patent Family Citations1
- 1
- Captures151
- Readers151
- 151
- Mentions1
- References1
- 1
Review Description
Over recent decades, various studies have argued that the metastatic tissue microenvironment is fully controlled by the intrinsic properties of the cancer cells (growth, motility and invasion, angiogenesis, extracellular matrix remodeling, immune escape) and additional cells types. Overall, the extrinsic factors and determinants mediate the contribution of the host microenvironment to metastasis formation. The tumor microenvironment carries out these functions by secretion of molecules that can influence and modulate its phenotype, making these complex interactions the basis for support for the progression of a cancer. Here, we undertake a summary of the "state of the art" of the functions and actions of these cells, as the main actors in the promotion of the formation of the microenvironment of the metastatic niche, and the associated network of interactions. The unraveling of the relationships between tumorigenic cells and their microenvironment represents an important issue for the development of new therapeutic agents that can fight both initiation and recurrence of cancer. © 2012 Springer Science+Business Media B.V.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84859715721&origin=inward; http://dx.doi.org/10.1007/s10585-012-9457-5; http://www.ncbi.nlm.nih.gov/pubmed/22322279; http://link.springer.com/10.1007/s10585-012-9457-5; https://dx.doi.org/10.1007/s10585-012-9457-5; https://link.springer.com/article/10.1007/s10585-012-9457-5; http://www.springerlink.com/index/10.1007/s10585-012-9457-5; http://www.springerlink.com/index/pdf/10.1007/s10585-012-9457-5
Springer Science and Business Media LLC
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