PlumX Metrics
Embed PlumX Metrics

Tumor microenvironment: A main actor in the metastasis process

Clinical and Experimental Metastasis, ISSN: 0262-0898, Vol: 29, Issue: 4, Page: 381-395
2012
  • 168
    Citations
  • 0
    Usage
  • 151
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    168
  • Captures
    151
  • Mentions
    1
    • References
      1
      • 1

Review Description

Over recent decades, various studies have argued that the metastatic tissue microenvironment is fully controlled by the intrinsic properties of the cancer cells (growth, motility and invasion, angiogenesis, extracellular matrix remodeling, immune escape) and additional cells types. Overall, the extrinsic factors and determinants mediate the contribution of the host microenvironment to metastasis formation. The tumor microenvironment carries out these functions by secretion of molecules that can influence and modulate its phenotype, making these complex interactions the basis for support for the progression of a cancer. Here, we undertake a summary of the "state of the art" of the functions and actions of these cells, as the main actors in the promotion of the formation of the microenvironment of the metastatic niche, and the associated network of interactions. The unraveling of the relationships between tumorigenic cells and their microenvironment represents an important issue for the development of new therapeutic agents that can fight both initiation and recurrence of cancer. © 2012 Springer Science+Business Media B.V.

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know