A missense mutation (c.1963A
Molecular Biology Reports, ISSN: 0301-4851, Vol: 39, Issue: 10, Page: 9291-9297
2012
- 4Citations
- 6Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Article Description
Serum Ca levels play important roles in the humoral immunity. The aim of this study was to detect quantitative trait loci and the associated positional candidate genes affecting baseline serum Ca concentrations. A genome-wide association study was conducted in an F intercross population between Landrace and Korean native pigs using the porcine single nucleotide polymorphism (SNP) 60 K beadchip and the PLINK program based on linear regression. Data used in the study included 410 F pigs. All experimental animals were genotyped with 36,613 SNP markers located throughout the pig autosomes. We identified a strong association between a SNP marker on chromosome 7 and serum Ca levels (DIAS0002191, genomic control-corrected P = 7.7 × 10). The position of DIAS0002191 was closely located to SLA class III region containing the C2 gene encoding the complementary component 2 protein, a protein which is important in the humoral immune responses. De novo sequencing of the porcine C2 gene revealed a missense mutation [c.1963A
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84868599468&origin=inward; http://dx.doi.org/10.1007/s11033-012-1679-8; http://www.ncbi.nlm.nih.gov/pubmed/22763733; http://link.springer.com/10.1007/s11033-012-1679-8; http://www.springerlink.com/index/10.1007/s11033-012-1679-8; http://www.springerlink.com/index/pdf/10.1007/s11033-012-1679-8; https://dx.doi.org/10.1007/s11033-012-1679-8; https://link.springer.com/article/10.1007/s11033-012-1679-8
Springer Science and Business Media LLC
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