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Efficient synthesis of 3,4-diarylpyrrole-2-carboxylates, the key fragments of natural antimitotic agents

Russian Chemical Bulletin, ISSN: 1573-9171, Vol: 67, Issue: 12, Page: 2316-2319
2018
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Barton-Zard reaction of nitrostilbenes with ethyl isocyanoacetate carried out in EtOH in the presence of KCO allowed us to minimize the formation of side products and to obtain 3,4-diarylpyrrole-2-carboxylates in high yields.

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