Successful Use of Easyhaler Dry Powder Inhaler in Patients with Chronic Obstructive Pulmonary Disease; Analysis of Peak Inspiratory Flow from Three Clinical Trials
Pulmonary Therapy, ISSN: 2364-1746, Vol: 10, Issue: 1, Page: 133-142
2024
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Most Recent News
Study Highlights New Findings on Dry Powder Inhaler Use Among COPD Patients
New findings suggest dry powder inhaler (DPI) use is not predicted by impaired expiratory lung function or characteristics of patients with chronic obstructive pulmonary disease
Article Description
Introduction: There is increasing pressure to use environmentally friendly dry powder inhalers (DPI) instead of pressurized metered-dose inhalers (pMDI). However, correct inhalation technique is needed for effective inhaler therapy, and there is persistent concern whether patients with chronic obstructive pulmonary disease (COPD) can generate sufficient inspiratory effort to use DPIs successfully. The aims of this study were to find clinical predictors for peak inspiratory flow rate (PIF) and to assess whether patients with COPD had difficulties in generating sufficient PIF with a high resistance DPI. Methods: Pooled data of 246 patients with COPD from previous clinical trials was analyzed to find possible predictors of PIF via the DPI Easyhaler (PIFEH) and to assess the proportion of patients able to achieve an inhalation flow rate of 30 l/min, which is needed to use the Easyhaler successfully. Results: The mean PIF was 56.9 l/min and 99% (243/246) of the study patients achieved a PIF ≥ 30 l/min. A low PIF was associated with female gender and lower forced expiratory volume in 1 s (FEV1), but the association was weak and a statistical model including both only accounted for 18% of the variation seen in PIFEH. Conclusions: Based on our results, impaired expiratory lung function or patient characteristics do not predict patients’ ability to use DPIs in COPD; 99% of the patients generated sufficient PIFEH for successful dose delivery. Considering the targets for sustainability in health care, this should be addressed as DPIs are a potential option for most patients when choosing the right inhaler for the patient. Trial Registration: Two of three included trials were registered under numbers NCT04147572 and NCT01424137. Third trial preceded registration platforms and therefore, was not registered.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85181240092&origin=inward; http://dx.doi.org/10.1007/s41030-023-00246-8; https://clinicaltrials.gov/ct2/show/NCT04147572; http://www.ncbi.nlm.nih.gov/pubmed/38170393; https://link.springer.com/10.1007/s41030-023-00246-8; https://dx.doi.org/10.1007/s41030-023-00246-8; https://link.springer.com/article/10.1007/s41030-023-00246-8
Springer Science and Business Media LLC
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