ACCORDION MIND: results of the observational extension of the ACCORD MIND randomised trial.

Citation data:

Diabetologia, ISSN: 1432-0428, Vol: 60, Issue: 1, Page: 69-80

Publication Year:
2017
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PMID:
27766347
DOI:
10.1007/s00125-016-4118-x
ClinicalTrials.gov Identifier:
NCT00182910
Author(s):
Murray, Anne M; Hsu, Fang-Chi; Williamson, Jeff D; Bryan, R Nick; Gerstein, Hertzel C; Sullivan, Mark D; Miller, Michael E; Leng, Iris; Lovato, Laura L; Launer, Lenore J; Action to Control Cardiovascular Risk in Diabetes Follow-On Memory in Diabetes (ACCORDION MIND) Investigators Show More Hide
Publisher(s):
Springer Nature
Tags:
Medicine
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article description
The Memory in Diabetes (MIND) substudy of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study, a double 2x2 factorial parallel-group randomised clinical trial, tested whether intensive compared with standard management of hyperglycaemia, BP or lipid levels reduced cognitive decline and brain atrophy in 2977 people with type 2 diabetes. We describe the results of the observational extension study, ACCORDION MIND (ClinicalTrials.gov registration no. NCT00182910), which aimed to measure the long-term effects of the three ACCORD interventions on cognitive and brain structure outcomes approximately 4 years after the trial ended.