Mechanisms of Antioxidant Induction with High-Dose N-Acetylcysteine in Childhood Cerebral Adrenoleukodystrophy.

Citation data:

CNS drugs, ISSN: 1179-1934, Vol: 29, Issue: 12, Page: 1041-7

Publication Year:
2015
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PMID:
26670322
DOI:
10.1007/s40263-015-0300-9
Author(s):
Kartha, Reena V, Zhou, Jie, Basso, Lisa, Schröder, Henning, Orchard, Paul J, Cloyd, James
Publisher(s):
Springer Nature
Tags:
Medicine
article description
Childhood cerebral adrenoleukodystrophy (CCALD), a progressive demyelinating disease affecting school-aged boys, causes death within a few years. Oxidative stress is an important contributing factor. N-acetylcysteine (NAC; 280 mg/kg/day) added as adjunctive therapy to reduced-intensity hematopoietic cell transplantation (HCT) improves survival in advanced cases. However, the mechanisms underlying the benefits of NAC are unclear.

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