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Urinary excretion of free glucocorticosteriods and testosterone in the Mongolian gerbil ( Meriones unguiculatus ): Effects of long-acting corticotrophin and human gonadotrophin

Comparative Biochemistry and Physiology Part A: Physiology, ISSN: 0300-9629, Vol: 91, Issue: 4, Page: 789-795
1988
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  • Citations
    14
    • Citation Indexes
      14

Article Description

1.1. Methods for the quantitative collection of 24-hr urines of small laboratory animals and for the measurement of urinary free glucocorticosteroids and testosterone are described.2.2. Urinary glucocorticosteroids and testosterone were determined in 0.1–0.5 ml-aliquots of 1100 diluted urines after kieselgur mini-column extraction.3.3. Excretion of glucocorticosteroids and testosterone in undisturbed Mongolian gerbils was 329 and 13 ng/day, respectively.4.4. Administration of long-acting (1–24)ACTH (20 IU/animal) increased glucocorticosteroid and testosterone excretion to about 2000 ng/day (glucocorticosteriods) and to about 30 ng/day (testosterone) over 3 days.5.5. In animals injected with 100 IU/animal HCG, testosterone excretion was elevated to about 35–50 ng/day over 3 days.6.6. As the results show, the measurement of urinary excretion of free glucocorticosteroids and testosterone is a relable index of adrenal-gonadal function in the Mongolian gerbil.7.7. Furthermore, in small laboratory animals, steroid measurements in 24-hr urines may be superior to determinations in plasma, since amounts of urinary steroid are relatively high and 24-hr urines can be collected over longer time periods without stressing the animals.

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