Tonic GABA secretion of cultured rat hippocampal neurons rapidly transformed by Zn 2+ into quantal release
Neuroscience Letters, ISSN: 0304-3940, Vol: 158, Issue: 2, Page: 125-129
1993
- 18Citations
- 17Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations18
- Citation Indexes18
- 18
- CrossRef14
- Captures17
- Readers17
- 17
Article Description
Different mechanisms of neurotransmitter secretion at synapses have been ascribed to quantal, transient signals [4–9] and to continuous, tonic activity [11, 21, 25]. Quantal transmission is imputed to be the release of transmitter packets, or quanta [6], assembled and stored in vesicles present in presynaptic terminals [2, 8]. We report that 300 μM Zn 2+ rapidly transformed tonic Cl − conductance mediated by the transmitter γ-aminobutyric acid (GABA) into transient synaptic-like signals. After addition of Zn 2+, the size of the elementary fluctuations in the Cl − current progressively increased while randomly activated Cl − channel kinetics remained unchanged and accounted for the bi-exponential time course of average transient decay. The results suggest that Zn 2+ rapidly transforms tonic GABA secretion into quantal-like transient release.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/030439409390245G; http://dx.doi.org/10.1016/0304-3940(93)90245-g; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0027291917&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/8233083; https://linkinghub.elsevier.com/retrieve/pii/030439409390245G; http://linkinghub.elsevier.com/retrieve/pii/030439409390245G; http://api.elsevier.com/content/article/PII:030439409390245G?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:030439409390245G?httpAccept=text/plain; http://dx.doi.org/10.1016/0304-3940%2893%2990245-g; https://dx.doi.org/10.1016/0304-3940%2893%2990245-g
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