Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbα antagonism: a single-centre propensity-matched cohort study and a randomised study.

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Lancet (London, England), ISSN: 1474-547X, Vol: 391, Issue: 10115, Page: 59-69

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10.1016/s0140-6736(17)32132-3; 10.3410/f.732035219.793538343; 10.3410/f.732035219.793539763 Identifier:
Montaigne, David; Marechal, Xavier; Modine, Thomas; Coisne, Augustin; Mouton, Stéphanie; Fayad, Georges; Ninni, Sandro; Klein, Cédric; Ortmans, Staniel; Seunes, Claire; Potelle, Charlotte; Berthier, Alexandre; Gheeraert, Celine; Piveteau, Catherine; Deprez, Rebecca; Eeckhoute, Jérome; Duez, Hélène; Lacroix, Dominique; Deprez, Benoit; Jegou, Bruno; Koussa, Mohamed; Edme, Jean-Louis; Lefebvre, Philippe; Staels, Bart Show More Hide
Elsevier BV; Faculty of 1000, Ltd.
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article description
On-pump cardiac surgery provokes a predictable perioperative myocardial ischaemia-reperfusion injury which is associated with poor clinical outcomes. We determined the occurrence of time-of-the-day variation in perioperative myocardial injury in patients undergoing aortic valve replacement and its molecular mechanisms.