Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbα antagonism: a single-centre propensity-matched cohort study and a randomised study.

Citation data:

Lancet (London, England), ISSN: 1474-547X

Publication Year:
2017
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PMID:
29107324
DOI:
10.1016/s0140-6736(17)32132-3
Author(s):
Montaigne, David, Marechal, Xavier, Modine, Thomas, Coisne, Augustin, Mouton, Stéphanie, Fayad, Georges, Ninni, Sandro, Klein, Cédric, Ortmans, Staniel, Seunes, Claire, Potelle, Charlotte, Berthier, Alexandre, Gheeraert, Celine, Piveteau, Catherine, Deprez, Rebecca, Eeckhoute, Jérome, Duez, Hélène, Lacroix, Dominique, Deprez, Benoit, Jegou, Bruno, Koussa, Mohamed, Edme, Jean-Louis, Lefebvre, Philippe, Staels, Bart Show More Hide
Publisher(s):
Elsevier BV
Tags:
Medicine
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article description
On-pump cardiac surgery provokes a predictable perioperative myocardial ischaemia-reperfusion injury which is associated with poor clinical outcomes. We determined the occurrence of time-of-the-day variation in perioperative myocardial injury in patients undergoing aortic valve replacement and its molecular mechanisms.

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