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Functionalization of self-assembling peptides for neural tissue engineering

Self-assembling Biomaterials, Page: 475-493
2018
  • 13
    Citations
  • 0
    Usage
  • 23
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    13
    • Citation Indexes
      13
  • Captures
    23

Book Chapter Description

It has become increasingly accepted that biomimetic bioabsorbable biomaterials are pivotal for improving neural tissue engineering. In this context, self-assembling peptides (SAPs) provide a versatile platform for multiple functionalizations targeting specific regenerative therapies. While the SAP synthesis process is suited for multiple functionalizations, the integration of functional motifs into SAPs needs to be carefully considered for not impairing self-assembly and ensuring proper exposure of functional motifs for optimal interactions with cells and tissues. Also, solubility and mechanical properties may be significantly altered. Data from molecular modeling, screening of functional motif libraries, in vitro tests and biomechanic studies can provide insightful information to design SAP scaffolds to promote functional nervous regeneration. Potential outcomes of this endeavor will be the setup of synthetic nervous organoids, of effective neural stem-cell carriers for transplants and feasible bioprostheses for the regeneration of nervous injuries.

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