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Delivery of antimigraine drugs to the brain through novel drug delivery systems

Novel Drug Delivery Systems in the management of CNS Disorders, Page: 371-392
2025
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Book Chapter Description

Migraine is the second most common cause of the neurological disorder that is characterized by a severe headache. The main goal of migraine treatment is to provide quick relief to the patient. However, the blood-brain barrier is the main constraint for drug penetration from the conventional dosage form. Additionally, erratic absorption and migraine-induced nausea and vomiting from the oral route limit the patient's compliance due to first-pass metabolism and delay in the onset of action. Many anti-migraine drugs currently used in treatment have low bioavailability and solubility. This imposes the need for novel drug delivery for existing drugs which can enhance drug delivery to the brain. Therefore, this review focused on all recent drug delivery systems developed for migraine treatment.

Bibliographic Details

Manisha Pandey; Jayashree Mayuren; null Pooja; Deepika Sharma; Tarun Kumar; Sunita Nirban; Adeel Masood Butt; Neha Jain; Bapi Gorain

Elsevier BV

Medicine; Pharmacology, Toxicology and Pharmaceutics

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