A novel fluorescent probe for detection of Glutathione dynamics during ROS-induced redox imbalance
Analytica Chimica Acta, ISSN: 0003-2670, Vol: 1115, Page: 52-60
2020
- 17Citations
- 9Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations17
- Citation Indexes17
- 17
- CrossRef4
- Captures9
- Readers9
Article Description
Monitoring cellular GSH dynamics is of great value to understand its complex biological functions and related diseases. It still remains challenging to understand the mechanism of GSH dynamics in complex intracellular environment. Herein, a novel fluorescent probe featured with chlorinated coumarin-TCF was exploited for sensing of GSH with high selectivity and high sensitivity. Large fluorescence enhancement at 471 nm was observed upon addition of GSH with large emission distance ( Δλ em = 219 nm). This novel probe was successfully applied to monitor endogenous and exogenous GSH dynamics without interference of other thiols via fluorescence imaging. More importantly, using this probe, low dose reactive oxygen species induced GSH increasement through nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signal pathway in BEL-7402 cells was observed. This novel fluorescent probe has the potential for quantitative monitoring of cellular GSH, which will promote further understanding of its physiological and pathological roles in biological systems.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0003267020302683; http://dx.doi.org/10.1016/j.aca.2020.02.059; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85083334786&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/32370869; https://linkinghub.elsevier.com/retrieve/pii/S0003267020302683; https://dx.doi.org/10.1016/j.aca.2020.02.059
Elsevier BV
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