Calcium Homeostasis Is Altered in Skeletal Muscle of Spontaneously Hypertensive Rats
The American Journal of Pathology, ISSN: 0002-9440, Vol: 184, Issue: 10, Page: 2803-2815
2014
- 2Citations
- 16Captures
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Metrics Details
- Citations2
- Citation Indexes2
- CrossRef1
- Captures16
- Readers16
- 14
Article Description
Hypertension is often associated with skeletal muscle pathological conditions related to function and metabolism. The mechanisms underlying the development of these pathological conditions remain undefined. Because calcium homeostasis is a biomarker of muscle function, we assessed whether it is altered in hypertensive muscles. We measured resting intracellular calcium and store-operated calcium entry (SOCE) in fast- and slow-twitch muscle fibers from normotensive Wistar-Kyoto rats and spontaneously hypertensive rats (SHRs) by cytofluorimetric technique and determined the expression of SOCE gene machinery by real-time PCR. Hypertension caused a phenotype-dependent dysregulation of calcium homeostasis; the resting intracellular calcium of extensor digitorum longus and soleus muscles of SHRs were differently altered with respect to the related muscle of normotensive animals. In addition, soleus muscles of SHR showed reduced activity of the sarcoplasmic reticulum and decreased sarcolemmal calcium permeability at rest and after SOCE activation. Accordingly, we found an alteration of the expression levels of some SOCE components, such as stromal interaction molecule 1, calcium release-activated calcium modulator 1, and transient receptor potential canonical 1. The hypertension-induced alterations of calcium homeostasis in the soleus muscle of SHRs occurred with changes of some functional outcomes as excitability and resting chloride conductance. We provide suitable targets for therapeutic interventions aimed at counterbalancing muscle performance decline in hypertension, and propose the reported calcium-dependent parameters as indexes to predict how the antihypertensive drugs could influence muscle function.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0002944014003769; http://dx.doi.org/10.1016/j.ajpath.2014.06.020; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84922470057&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/25084345; https://linkinghub.elsevier.com/retrieve/pii/S0002944014003769; http://ajp.amjpathol.org/article/S0002-9440(14)00376-9/abstract
Elsevier BV
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