Susceptibility to streptozotocin-induced diabetes is mapped to mouse chromosome 11
Biochemical and Biophysical Research Communications, ISSN: 0006-291X, Vol: 328, Issue: 1, Page: 158-164
2005
- 21Citations
- 6Captures
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Metrics Details
- Citations21
- Citation Indexes21
- 21
- CrossRef19
- Captures6
- Readers6
Article Description
To study the contribution of β-cell vulnerability to susceptibility to diabetes, we studied β-cell vulnerability to a single high dose of streptozotocin (STZ) in an animal model of type 2 diabetes, the NSY mouse, a sister strain of the STZ-sensitive NOD mouse, in comparison with the STZ-resistant C3H mouse. NSY mice were found to be extremely sensitive to STZ. Introgression of a single Chr 11, where STZ-sensitivity was mapped in the NOD mouse, from NSY mice converted STZ-resistant C3H mice to STZ-sensitive. Two nucleotide substitutions were identified in the nucleoredoxin gene, a positional and functional candidate gene for STZ-induced diabetes on Chr 11. These data, together with the co-localization of type 1 ( Idd4 ) and type 2 ( Nidd1n ) susceptibility genes on Chr 11, suggest that the intrinsic vulnerability of pancreatic β cells is determined by a gene or genes on Chr 11, which may also contribute to susceptibility to spontaneous diabetes.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0006291X04029778; http://dx.doi.org/10.1016/j.bbrc.2004.12.149; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=12844275358&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/15670764; https://linkinghub.elsevier.com/retrieve/pii/S0006291X04029778; https://dx.doi.org/10.1016/j.bbrc.2004.12.149
Elsevier BV
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