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Extramitochondrial tricarboxylic acid cycle in retinal rod outer segments

Biochimie, ISSN: 0300-9084, Vol: 93, Issue: 9, Page: 1565-1575
2011
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Article Description

Vertebrate retinal rod Outer Segments (OS) are the site of visual transduction, an energy demanding process for which mechanisms of ATP supply are still poorly known. Glycolysis or diffusion of either ATP or phosphocreatine from the Inner Segment (IS) does not seem to display adequate timing to supply ATP for phototransduction. We have previously reported data suggesting an aerobic metabolism in OS, which would largely account for the light-stimulated ATP need of the photoreceptor.

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