Electrochemical nanobiosensor for express diagnosis of acute myocardial infarction in undiluted plasma
Biosensors and Bioelectronics, ISSN: 0956-5663, Vol: 25, Issue: 7, Page: 1694-1698
2010
- 82Citations
- 68Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations82
- Citation Indexes82
- 82
- CrossRef69
- Captures68
- Readers68
- 68
Article Description
The myocardial infarction biomarker myoglobin was quantified at the biological level in undiluted plasma using developed electrochemical nanosensors with immobilized anti-myoglobin. Method for cardiac myoglobin detection is based on direct electron transfer between Fe(III)-heme and electrode surface modified with gold nanoparticles/didodecyldimethylammonium bromide (DDAB/Au) and antibodies. The procedure of myoglobin detection was optimized (pH, incubation times and characteristics of electrodes) to express determination of the marker in serum or plasma. Plasma of healthy donors and patients with acute myocardial infarction (AMI) was analyzed using electrochemical immunosensors and RAMP ® immunoassay. Square wave voltammetry cathodic peak of cardiac myoglobin reduction was found to be proportional to myoglobin quantity in plasma as determined by RAMP ®. The method proposed does not require signal enhancement or amplification; nor does it require labeled secondary antibodies. Immunosensor has a detection limit of 10 ng/ml (0.56 nM) and a broad range of working concentrations (10–1780 ng/ml; 0.56–100 nM). The whole procedure takes 30 min and can be used for express diagnosis of acute myocardial infarction.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0956566309006575; http://dx.doi.org/10.1016/j.bios.2009.12.009; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77952301534&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/20060282; https://linkinghub.elsevier.com/retrieve/pii/S0956566309006575; https://dx.doi.org/10.1016/j.bios.2009.12.009
Elsevier BV
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