Tricyclic pyrazoles. Part 2: Synthesis and biological evaluation of novel 4,5-dihydro-1 H -benzo[ g ]indazole-based ligands for cannabinoid receptors
Bioorganic & Medicinal Chemistry, ISSN: 0968-0896, Vol: 13, Issue: 9, Page: 3309-3320
2005
- 60Citations
- 22Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations60
- Citation Indexes58
- 58
- CrossRef46
- Patent Family Citations2
- Patent Families2
- Captures22
- Readers22
- 22
Article Description
A series of 4,5-dihydro-1 H -benzo[ g ]indazole-3-carboxamides ( 2a – k ) as analogues of the previously reported CB 2 ligands 6-chloro- and 6-methyl-1-(2′,4′-dichlorophenyl)- N -piperidin-1-yl-1,4-dihydroindeno[1,2- c ]pyrazole-3-carboxamides ( 1a, b ) was synthesized and their affinity and selectivity towards CB 1 and CB 2 receptors were evaluated. Several of the new compounds ( 2a, b, c, d and i ) exhibited CB 1 affinity in the nanomolar range with moderate or negligible affinity towards CB 2 receptors. Compounds 2a and c increased intestinal propulsion in mouse. Their pro-kinetic effects were reversed by the reference CB agonist CP-55,940. Consequently, in vivo CB 1 antagonistic activity was highlighted for these compounds.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0968089605001483; http://dx.doi.org/10.1016/j.bmc.2005.02.032; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=16244420759&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/15809166; https://linkinghub.elsevier.com/retrieve/pii/S0968089605001483; https://dx.doi.org/10.1016/j.bmc.2005.02.032
Elsevier BV
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