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Bulky 1,4-benzoxazine derivatives with antifungal activity

Bioorganic & Medicinal Chemistry, ISSN: 0968-0896, Vol: 17, Issue: 11, Page: 3838-3846
2009
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Article Description

For many years the development of new azole antifungals has been quite empirically based. More recently, the publication of the crystal structure of CYP51 of Mycobacterium tuberculosis (MT-CYP51) provided new opportunities to rationalize the knowledge about antifungal action of this class of compounds.

Bibliographic Details

Fringuelli, Renata; Giacchè, Nicola; Milanese, Lara; Cenci, Elio; Macchiarulo, Antonio; Vecchiarelli, Anna; Costantino, Gabriele; Schiaffella, Fausto

Elsevier BV

Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics; Chemistry

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