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Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers

Bioorganic & Medicinal Chemistry Letters, ISSN: 0960-894X, Vol: 17, Issue: 8, Page: 2233-2236
2007
  • 209
    Citations
  • 0
    Usage
  • 50
    Captures
  • 0
    Mentions
  • 1
    Social Media
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Metrics Details

  • Citations
    209
  • Captures
    50
  • Social Media
    1
    • Shares, Likes & Comments
      1
      • Facebook
        1

Article Description

In this study, a series of novel phenyl- and benzimidazole-substituted benzyl ethers were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Methicillin-resistant S. aureus (MRSA), Escherichia coli, Candida albicans, and Candida krusei. Compound 6g exhibited the most potent antibacterial activity with lowest MIC values of 3.12 and 6.25 μg/mL against S. aureus and MRSA, respectively.

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