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Gold nanoparticles capped with sulfate-ended ligands as anti-HIV agents

Bioorganic & Medicinal Chemistry Letters, ISSN: 0960-894X, Vol: 20, Issue: 9, Page: 2718-2721
2010
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Article Description

Gold nanoparticles coated with multiple copies of an amphiphilic sulfate-ended ligand are able to bind the HIV envelope glycoprotein gp120 as measured by surface plasmon resonance (SPR) and inhibit in vitro the HIV infection of T-cells at nanomolar concentrations. A 50% density of sulfated ligands on ∼2 nm nanoparticles (the other ligands being inert glucose derivatives) is enough to achieve high anti-HIV activities. This result opens up the possibility of tailoring both sulfated ligands and other anti-HIV molecules on the same gold cluster, thus contributing to the development of non-cocktail based multifunctional anti-HIV systems.

Bibliographic Details

Di Gianvincenzo, Paolo; Marradi, Marco; Martínez-Avila, Olga María; Bedoya, Luis Miguel; Alcamí, José; Penadés, Soledad

Elsevier BV

Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics; Chemistry

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