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Autocrine human growth hormone stimulates the tumor initiating capacity and metastasis of estrogen receptor-negative mammary carcinoma cells

Cancer Letters, ISSN: 0304-3835, Vol: 365, Issue: 2, Page: 182-189
2015
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Autocrine human growth hormone stimulates the tumor initiating capacity and metastasis of estrogen receptor-negative mammary carcinoma cells.

Authors: Yi-Jun Chen, Xiao Zhang, Zheng-Sheng Wu, Jing-Jing Wang, Amy Yong-Chen Lau, Tao Zhu, Peter E Lobie PMID: 26070963 DOI: 10.1016/j.canlet.2015.05.031 Publication Type: Research Support,

Article Description

The oncogenic effects of autocrine human growth hormone (hGH) have been intensively investigated in estrogen receptor-positive mammary carcinoma (ER + MC) cells. We demonstrated herein that autocrine hGH promoted cancer stem cell (CSC)-like properties of estrogen receptor-negative mammary carcinoma (ER-MC) cells in vitro. In xenograft studies, autocrine hGH increased the tumor initiating capacity of ER-MC cells. We also observed that autocrine hGH promoted migration and invasion of ER-MC cells in vitro, and metastasis in vivo. Thus, inhibition of hGH is a potential therapeutic strategy to prevent tumor initiation and metastasis of ER-MC.

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