The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites
Cell, ISSN: 0092-8674, Vol: 165, Issue: 7, Page: 1708-1720
2016
- 482Citations
- 756Captures
- 1Mentions
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations482
- Citation Indexes479
- 479
- CrossRef313
- Patent Family Citations3
- Patent Families3
- Captures756
- Readers756
- 689
- 55
- 12
- Mentions1
- News Mentions1
- News1
Most Recent News
β-Hydroxybutyrate suppresses colorectal cancer
Nature, Published online: 27 April 2022; doi:10.1038/s41586-022-04649-6 The growth of colorectal cancer is reduced by ketogenic diet consumption, the properties of which are mediated by the ketone body β-hydroxybutyrate.
Article Description
In the mammalian intestine, crypts of Leiberkühn house intestinal epithelial stem/progenitor cells at their base. The mammalian intestine also harbors a diverse array of microbial metabolite compounds that potentially modulate stem/progenitor cell activity. Unbiased screening identified butyrate, a prominent bacterial metabolite, as a potent inhibitor of intestinal stem/progenitor proliferation at physiologic concentrations. During homeostasis, differentiated colonocytes metabolized butyrate likely preventing it from reaching proliferating epithelial stem/progenitor cells within the crypt. Exposure of stem/progenitor cells in vivo to butyrate through either mucosal injury or application to a naturally crypt-less host organism led to inhibition of proliferation and delayed wound repair. The mechanism of butyrate action depended on the transcription factor Foxo3. Our findings indicate that mammalian crypt architecture protects stem/progenitor cell proliferation in part through a metabolic barrier formed by differentiated colonocytes that consume butyrate and stimulate future studies on the interplay of host anatomy and microbiome metabolism.
Bibliographic Details
10.1016/j.cell.2016.05.018; 10.3410/f.726403577.793519850; 10.3410/f.726403577.793520086; 10.3410/f.726403577.793523283
http://www.sciencedirect.com/science/article/pii/S0092867416305669; http://dx.doi.org/10.1016/j.cell.2016.05.018; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84973666361&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/27264604; https://facultyopinions.com/prime/726403577#eval793519850; http://dx.doi.org/10.3410/f.726403577.793519850; https://linkinghub.elsevier.com/retrieve/pii/S0092867416305669; https://facultyopinions.com/prime/726403577#eval793520086; http://dx.doi.org/10.3410/f.726403577.793520086; https://facultyopinions.com/prime/726403577#eval793523283; http://dx.doi.org/10.3410/f.726403577.793523283; http://f1000.com/prime/726403577#eval793520086; http://f1000.com/prime/726403577#eval793523283; http://linkinghub.elsevier.com/retrieve/pii/S0092867416305669; https://www.cell.com/fulltext/S0092-8674(16)30566-9; http://www.cell.com/article/S0092867416305669/abstract; http://www.cell.com/article/S0092867416305669/fulltext; http://www.cell.com/article/S0092867416305669/pdf; https://www.cell.com/cell/abstract/S0092-8674(16)30566-9
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