CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection
Cell Reports, ISSN: 2211-1247, Vol: 36, Issue: 11, Page: 109696
2021
- 92Citations
- 7Usage
- 120Captures
- 2Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations92
- Citation Indexes92
- 92
- CrossRef20
- Usage7
- Downloads6
- Abstract Views1
- Captures120
- Readers120
- 120
- Mentions2
- News Mentions2
- News2
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Article Description
CD4 T cells are essential for immunity to tuberculosis because they produce cytokines, including interferon-γ. Whether CD4 T cells act as “helper” cells to promote optimal CD8 T cell responses during Mycobacterium tuberculosis is unknown. Using two independent models, we show that CD4 T cell help enhances CD8 effector functions and prevents CD8 T cell exhaustion. We demonstrate synergy between CD4 and CD8 T cells in promoting the survival of infected mice. Purified helped, but not helpless, CD8 T cells efficiently restrict intracellular bacterial growth in vitro. Thus, CD4 T cell help plays an essential role in generating protective CD8 T cell responses against M. tuberculosis infection in vitro and in vivo. We infer vaccines that elicit both CD4 and CD8 T cells are more likely to be successful than vaccines that elicit only CD4 or CD8 T cells.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S2211124721011438; http://dx.doi.org/10.1016/j.celrep.2021.109696; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85114792970&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/34525366; https://linkinghub.elsevier.com/retrieve/pii/S2211124721011438; https://escholarship.umassmed.edu/oapubs/4932; https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5967&context=oapubs; https://dx.doi.org/10.1016/j.celrep.2021.109696
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