Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo

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Chem, ISSN: 2451-9294, Vol: 3, Issue: 3, Page: 437-460

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Haobo Ge; Patrick J. Riss; Vincenzo Mirabello; David G. Calatayud; Stephen E. Flower; Rory L. Arrowsmith; Tim D. Fryer; Young Hong; Steve Sawiak; Robert M.J. Jacobs; Stanley W. Botchway; Rex M. Tyrrell; Tony D. James; John S. Fossey; Jonathan R. Dilworth; Franklin I. Aigbirhio; Sofia I. Pascu Show More Hide
Elsevier BV
Chemistry; Biochemistry, Genetics and Molecular Biology; Environmental Science; Chemical Engineering; Medicine; Materials Science
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article description
Hybrid materials based on supramolecularly assembled single-walled carbon nanotubes (SWNTs) are generated for positron emission tomography (PET), magnetic resonance imaging, and fluorescence imaging. The all-in-one imaging probe allows quantitative imaging from subcellular resolution to whole tissue regions. The SWNTs can be exposed to aqueous solutions of non-radioactive and radioactive metal salts in the presence of fullerenes and β- d -glucan. Encapsulating 64 Cu ions achieves a minimum of 69% incorporation of radiochemical. The results suggest that this method can be extended to other metal ions of medical relevance, such as zirconium(IV)-89 or rhenium(VII)-188, which are used for medical imaging or radiotherapy, respectively. The in vivo uptake of 64 Cu(II)@SWNT@β- d -glucan in Wistar rats allows the investigation of organ biodistribution by microPET. Radioactivity rapidly accumulates predominantly in the lungs and myocardium with peak uptakes of 4.8 ± 0.9 standardized uptake value. Furthermore, such materials are fully traceable in cells by multiphoton fluorescence lifetime imaging with near-infrared excitation (910 nm).