Genetic Drift during Systemic Arbovirus Infection of Mosquito Vectors Leads to Decreased Relative Fitness during Host Switching
Cell Host & Microbe, ISSN: 1931-3128, Vol: 19, Issue: 4, Page: 481-492
2016
- 107Citations
- 223Captures
- 2Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations107
- Citation Indexes107
- CrossRef107
- 101
- Captures223
- Readers223
- 221
- Mentions2
- News Mentions2
- News2
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Virus evolution differs by species of mosquito carrier
A new study on how the West Nile virus evolves in four species of mosquitos shows that viruses accumulate mutations in their insect carriers that
Article Description
The emergence of mosquito-borne RNA viruses, such as West Nile virus (WNV), is facilitated by genetically complex virus populations within hosts. Here, we determine whether WNV enzootic ( Culex tarsalis, Cx. quinquefasciatus, and Cx. pipiens ) and bridge vectors ( Aedes aegypti ) have differential impacts on viral mutational diversity and fitness. During systemic mosquito infection, WNV faced stochastic reductions in genetic diversity that rapidly was recovered during intra-tissue population expansions. Interestingly, this intrahost selection and diversification was mosquito species dependent with Cx. tarsalis and Cx. quinquefasciatus exhibiting greater WNV divergence. However, recovered viral populations contained a preponderance of potentially deleterious mutations (i.e., high mutational load) and had lower relative fitness in avian cells compared to input virus. These findings demonstrate that the adaptive potential associated with mosquito transmission varies depending on the mosquito species and carries a significant fitness cost in vertebrates.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1931312816300944; http://dx.doi.org/10.1016/j.chom.2016.03.002; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84962094612&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/27049584; https://facultyopinions.com/prime/726268110#eval793522296; http://dx.doi.org/10.3410/f.726268110.793522296; https://linkinghub.elsevier.com/retrieve/pii/S1931312816300944; https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(16)30094-4; http://www.cell.com/article/S1931312816300944/abstract; http://www.cell.com/article/S1931312816300944/fulltext; http://www.cell.com/article/S1931312816300944/pdf; https://www.cell.com/cell-host-microbe/abstract/S1931-3128(16)30094-4; http://f1000.com/prime/726268110#eval793522296; http://linkinghub.elsevier.com/retrieve/pii/S1931312816300944; https://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=http://www.cell.com/cell-host-microbe/abstract/S1931-3128(16)30094-4&rc=0&code=cell-site; http://www.cell.com/cell-host-microbe/abstract/S1931-3128(16)30094-4
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