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Modeling chronic hepatitis B or C virus infection during antiviral therapy using an analogy to enzyme kinetics: Long-term viral dynamics without rebound and oscillation

Computers in Biology and Medicine, ISSN: 0010-4825, Vol: 43, Issue: 12, Page: 2021-2027
2013
  • 2
    Citations
  • 0
    Usage
  • 8
    Captures
  • 0
    Mentions
  • 26
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    2
    • Citation Indexes
      2
  • Captures
    8
  • Social Media
    26
    • Shares, Likes & Comments
      26
      • Facebook
        26

Article Description

The basic model for chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection during therapy enables us to analyze short-term viral kinetics. However, the model is not useful for analyzing long-term viral kinetics. Here, I suggest a new model that was obtained by introducing Michaelis–Menten kinetics into the basic model. The new model can exhibit long-term viral kinetics without rebound and oscillation, unlike the basic model. The value of the parameter K in the new model is analogous to the Michaelis constant K m and is predicted to be approximately less than 10 10 /ml.

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