Modeling chronic hepatitis B or C virus infection during antiviral therapy using an analogy to enzyme kinetics: Long-term viral dynamics without rebound and oscillation
Computers in Biology and Medicine, ISSN: 0010-4825, Vol: 43, Issue: 12, Page: 2021-2027
2013
- 2Citations
- 8Captures
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Article Description
The basic model for chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection during therapy enables us to analyze short-term viral kinetics. However, the model is not useful for analyzing long-term viral kinetics. Here, I suggest a new model that was obtained by introducing Michaelis–Menten kinetics into the basic model. The new model can exhibit long-term viral kinetics without rebound and oscillation, unlike the basic model. The value of the parameter K in the new model is analogous to the Michaelis constant K m and is predicted to be approximately less than 10 10 /ml.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S001048251300276X; http://dx.doi.org/10.1016/j.compbiomed.2013.09.025; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84886499700&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/24290917; https://linkinghub.elsevier.com/retrieve/pii/S001048251300276X; http://www.computersinbiologyandmedicine.com/article/S0010-4825(13)00276-X/abstract
Elsevier BV
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