Effects of subchronic samarium exposure on the histopathological structure and apoptosis regulation in mouse testis
Environmental Toxicology and Pharmacology, ISSN: 1382-6689, Vol: 37, Issue: 2, Page: 505-512
2014
- 33Citations
- 20Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations33
- Citation Indexes33
- 33
- CrossRef19
- Captures20
- Readers20
- 20
Article Description
To evaluate the reproductive toxicity of samarium, a widely used rare earth element, male ICR mice were orally exposed to samarium nitrate for 90 days for lesion evaluation in the testis. Decreased organ coefficients, disorganized seminiferous tubules, and decreased spermatogenic cells and sperm of the testis were observed extensively in the treated groups, indicating that the testis is a target organ of samarium. Electron microscopy confirmed that the lesions inside the spermatogenic cells and sperm mainly included mitochondrial swelling, mitochondrial vacuolization, fuzzy nuclear membranes, and marginated chromatin. Increased spermatogenic cell apoptosis rate in the testis was confirmed with a TUNEL assay. And expression up-regulation of p53 and Bax, and down-regulation of Bcl-2 were observed ( p < 0.05), indicating the apoptosis is related to p53 mediated pathway.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1382668914000088; http://dx.doi.org/10.1016/j.etap.2014.01.007; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84894228846&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/24561534; https://linkinghub.elsevier.com/retrieve/pii/S1382668914000088; https://dx.doi.org/10.1016/j.etap.2014.01.007
Elsevier BV
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