Atractylenolide III, a sesquiterpenoid, induces apoptosis in human lung carcinoma A549 cells via mitochondria-mediated death pathway
Food and Chemical Toxicology, ISSN: 0278-6915, Vol: 49, Issue: 2, Page: 514-519
2011
- 63Citations
- 12Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations63
- Citation Indexes63
- 63
- CrossRef44
- Captures12
- Readers12
- 12
- Mentions1
- News Mentions1
- News1
Most Recent News
Protective Effects of Atractylodes macrocephala Polysaccharide on iIELs and the IL-6, TNF-α mRNA Level in E. coli induced Diarrheal Mice
Key words Atractylodes macrocephala polysaccharide, Lymphocytes, IL-6, TNF-α INTRODUCTION Diarrhea is a common problem with public health and animals, one of the leading causes of
Article Description
Pharmacological agents that are safe and can sensitize the lung cancer are urgently required. We investigated whether Atractylenolide III (ATL-III), the major component of Atractylodes rhizome can induce apoptosis of the lung carcinoma cells. ATL-III inhibited cell growth, increased lactate dehydrogenase release and modulated cell cycle on human lung carcinoma A549 cells. ALT-III induced the activation of caspase-3 and caspase-9 and cleavage of poly-(ADP)-ribose polymerase. ATL-III induced the release of cytochrome c, upregulation of bax expression, and translocation of apoptosis-inducing factor. In addition, ATL-III inhibited the proliferation and capillary tube formation of human umbilical vein endothelial cells. These data indicate that ATL-III is a potential candidate for treatment of human lung carcinoma.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0278691510006964; http://dx.doi.org/10.1016/j.fct.2010.11.038; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78951484329&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/21130827; https://linkinghub.elsevier.com/retrieve/pii/S0278691510006964; https://dx.doi.org/10.1016/j.fct.2010.11.038
Elsevier BV
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