Interaction effects between macromolecules and photosensitizer on the ability of AlPc and InPc-loaded PHB magnetic nanoparticles in photooxidatizing simple biomolecules
International Journal of Biological Macromolecules, ISSN: 0141-8130, Vol: 212, Page: 579-593
2022
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Article Description
The parameters used in the preparation of polymeric nanoparticles can influence its ability to photooxidate biomolecules. This work evaluated the effects of four parameter to prepare Poly(3-hydroxybutyrate) (PHB) nanoparticle loaded with aluminum and indium phthalocyanine (AlPc and InPc), together with iron oxide nanoparticles, assessing their influence on the size, the entrapment efficiency, and the nanoparticles recovery efficacy. The capability of free, and encapsulated, AlPc and InPc in photooxidating the bovine serum albumin (BSA) and tryptophan (Trp) was monitored by fluorescence. The AlPc-loaded nanoparticles had a larger size and a greater entrapment efficiency than that obtained by InPc-loaded nanoparticles. The free InPc was more efficient than the free AlPc to photooxidize the BSA and Trp; whereas the encapsulated AlPc was more efficient than encapsulated InPc to photooxidize the biomolecules. The higher hydrophobicity of the AlPc, combined with the greater aggregation state and the major interaction with the BSA, quenching the capacity of the free AlPc to photooxidate the biomolecules; whereas the greater interaction of the AlPc with PHB reduce the aggregation effect on the free molecules in the aqueous phase and increase the entrapment efficiency, resulting in an improving of the photodynamic efficiency and an increase of the photooxidation rate constant.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0141813022011151; http://dx.doi.org/10.1016/j.ijbiomac.2022.05.135; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85130909126&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/35618092; https://linkinghub.elsevier.com/retrieve/pii/S0141813022011151; https://dx.doi.org/10.1016/j.ijbiomac.2022.05.135
Elsevier BV
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