Critical Role of STAT5 Transcription Factor Tetramerization for Cytokine Responses and Normal Immune Function
Immunity, ISSN: 1074-7613, Vol: 36, Issue: 4, Page: 586-599
2012
- 152Citations
- 202Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations152
- Citation Indexes152
- 152
- CrossRef149
- Captures202
- Readers202
- 202
- Mentions1
- News Mentions1
- 1
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Article Description
Cytokine-activated STAT proteins dimerize and bind to high-affinity motifs, and N-terminal domain-mediated oligomerization of dimers allows tetramer formation and binding to low-affinity tandem motifs, but the functions of dimers versus tetramers are unknown. We generated Stat5a-Stat5b double knockin (DKI) N-domain mutant mice in which STAT5 proteins form dimers but not tetramers, identified cytokine-regulated genes whose expression required STAT5 tetramers, and defined dimer versus tetramer consensus motifs. Whereas Stat5 -deficient mice exhibited perinatal lethality, DKI mice were viable; thus, STAT5 dimers were sufficient for survival. Nevertheless, STAT5 DKI mice had fewer CD4 + CD25 + T cells, NK cells, and CD8 + T cells, with impaired cytokine-induced and homeostatic proliferation of CD8 + T cells. Moreover, DKI CD8 + T cell proliferation after viral infection was diminished and DKI Treg cells did not efficiently control colitis. Thus, tetramerization of STAT5 is critical for cytokine responses and normal immune function, establishing a critical role for STAT5 tetramerization in vivo.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1074761312001409; http://dx.doi.org/10.1016/j.immuni.2012.02.017; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84859968982&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/22520852; https://facultyopinions.com/prime/717047802#eval792352804; http://dx.doi.org/10.3410/f.717047802.792352804; https://linkinghub.elsevier.com/retrieve/pii/S1074761312001409; http://www.cell.com/immunity/abstract/S1074-7613(12)00140-9?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761312001409%3Fshowall%3Dtrue; http://www.cell.com/article/S1074761312001409/abstract; http://www.cell.com/article/S1074761312001409/fulltext; http://www.cell.com/article/S1074761312001409/pdf; http://f1000.com/717047802#eval792352804; http://linkinghub.elsevier.com/retrieve/pii/S1074761312001409
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