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Association of preoperative monocyte/lymphocyte ratio with postoperative oxygenation impairment in patients with acute aortic syndrome

International Immunopharmacology, ISSN: 1567-5769, Vol: 118, Page: 110067
2023
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  • 7
    Captures
  • 1
    Mentions
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Metric Options:   Counts1 Year3 Year

Metrics Details

  • Captures
    7
  • Mentions
    1
    • News Mentions
      1
      • 1

Most Recent News

Central South University Reports Findings in Mononuclear Phagocyte System (Association of preoperative monocyte/lymphocyte ratio with postoperative oxygenation impairment in patients with acute aortic syndrome)

2023 APR 25 (NewsRx) -- By a News Reporter-Staff News Editor at Chemicals & Chemistry Daily Daily -- New research on Immunology - Mononuclear Phagocyte

Article Description

Postoperative oxygenation impairment represents a common complication in patients with the acute aortic syndrome (AAS). The study aimed to explore the relationship between inflammatory indicators and AAS patients with oxygenation impairment after operation. In this study, 330 AAS patients who underwent surgery were enrolled and divided into 2 groups based on postoperative oxygenation impairment (non-oxygenation impairment group and oxygenation impairment group). Regression analysis was performed to assess the relationship between inflammatory indicators and postoperative oxygenation impairment. A smooth curve and interaction analysis were further conducted. Stratified analysis was used according to preoperative monocyte/lymphocyte ratio (MLR) (Tertiles). Multivariate analysis showed that preoperative MLR was independently related to oxygenation impairment after surgery in AAS patients (OR, 95% CI, P : 2.77, 1.10–7.00, 0.031). The smooth curve indicated the risk of postoperative oxygenation impairment was higher with the elevated preoperative MLR. Interaction analysis revealed that patients with AAS with high preoperative MLR who had coronary artery disease (CAD) had a higher risk of oxygenation impairment after operation. Moreover, stratified analysis was performed according to baseline MLR (Tertiles), and a higher baseline MLR level in AAS patients was correlated with a lower arterial oxygen tension (P aO2 ) / inspiratory oxygen fraction (F iO2 ) ratio perioperatively. In AAS patients, preoperative MLR level was independently related to postoperative oxygenation impairment.

Bibliographic Details

Zhang, Chiyuan; Bai, Hui; Lin, Guoqiang; Zhang, Yanfeng; Zhang, Lei; Chen, Xuliang; Shi, Ruizheng; Zhang, Guogang; Fu, Zuli; Xu, Qian

Elsevier BV

Medicine; Immunology and Microbiology; Pharmacology, Toxicology and Pharmaceutics

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