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Deciphering signaling pathways in hematopoietic stem cells: the molecular complexity of Myelodysplastic Syndromes (MDS) and leukemic progression

Advances in Biological Regulation, ISSN: 2212-4926, Vol: 91, Page: 101014
2024
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Article Description

Myelodysplastic Syndromes, a heterogeneous group of hematological disorders, are characterized by abnormalities in phosphoinositide-dependent signaling, epigenetic regulators, apoptosis, and cytokine interactions within the bone marrow microenvironment, contributing to disease pathogenesis and neoplastic growth. Comprehensive knowledge of these pathways is crucial for the development of innovative therapies that aim to restore normal apoptosis and improve patient outcomes.

Bibliographic Details

Casalin, Irene; De Stefano, Alessia; Ceneri, Eleonora; Cappellini, Alessandra; Finelli, Carlo; Curti, Antonio; Paolini, Stefania; Parisi, Sarah; Zannoni, Letizia; Boultwood, Jacqueline; McCubrey, James A; Suh, Pann-Ghill; Ramazzotti, Giulia; Fiume, Roberta; Ratti, Stefano; Manzoli, Lucia; Cocco, Lucio; Follo, Matilde Y

Elsevier BV

Biochemistry, Genetics and Molecular Biology

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