Artemisia asiatica ethanol extract exhibits anti-photoaging activity
Journal of Ethnopharmacology, ISSN: 0378-8741, Vol: 220, Page: 57-66
2018
- 22Citations
- 37Captures
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Metrics Details
- Citations22
- Citation Indexes22
- 22
- CrossRef12
- Captures37
- Readers37
- 37
Article Description
Artemisia asiatica Nakai is a traditional herbal plant that has long been used in anti-inflammatory, anti-infective and skin protective remedies. In this study, traditionally known skin-protective activity of Artemisia asiatica Nakai was examined with its ethanol extract (Aa-EE) under various photoaging conditions using skin-originated cells, and the underlying mechanism was also examined using various types of cells. Effects of Aa-EE on cell viability, photocytotoxicity, and expression of matrix metalloproteinases (MMPs), cyclooxygenase (COX)-2, and moisturizing factors were measured in B16F10, HEK293, NIH3T3, and HaCaT cells under untreated and ultraviolet B (UVB)-irradiation conditions. Anti-melanogenic effect of Aa-EE was also examined by measuring both melanin content in B16F10 cells and tyrosinase activity. Anti-photoaging mechanism of Aa-EE was explored by determining the activation levels of signaling molecules by immunoblotting analysis. Aa-EE protected HaCaT cells from UVB irradiation-induced death. Aa-EE increased the expression of a type 1 pro-collagen gene and decreased the expression of matrix metalloproteinases, and COX-2 in NIH3T3 cells induced by UVB. Aa-EE increased the expression of transglutamase-1, hyaluronic acid synthase (HAS)-2, and HAS-3 in HaCaT cells and decreased the production of melanin in α-melanocyte-stimulating hormone-stimulated B16F10 cells by suppressing tyrosinase activity and the expression of tyrosinase, microphthalmia-associated transcription factor, tyrosinase-related protein (TRP)-1 and TRP-2. The results suggest that Aa-EE could be skin-protective remedy with anti-photoaging, anti-apoptotic, skin remodeling, moisturizing, and anti-melanogenesis properties.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0378874117337212; http://dx.doi.org/10.1016/j.jep.2018.03.037; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85044850658&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/29609010; https://linkinghub.elsevier.com/retrieve/pii/S0378874117337212; https://dx.doi.org/10.1016/j.jep.2018.03.037
Elsevier BV
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