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K index utility as diagnostic and prognostic biomarker in the assessment of patients with suspected Multiple Sclerosis

Journal of Neuroimmunology, ISSN: 0165-5728, Vol: 373, Page: 577992
2022
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Article Description

The aim of the present study is to evaluate the composite role of k index in the initial assessment of Multiple Sclerosis (MS) patients and to select useful cut-offs exportable in clinical practice. We analysed CSF/serum samples of 140 patients and followed-up the CIS/MS subgroup for 7 years. Our results suggest κ index as a quantitative diagnostic and prognostic biomarker in MS, significantly associated to baseline lesion load and to successive clinical course. We propose k index ≥106 as a prognostic cut-off to select patients at major risk of relapse, potentially influencing initial therapeutic decisions.

Bibliographic Details

Cutellè, Claudia; Balducci, Claudia; Cereda, Diletta; Fusco, Maria Letizia; Iacobucci, Davide; Perugini, Jacopo; Pirro, Fiammetta; Brivio, Rinaldo; Bernasconi, Davide Paolo; Ferrarese, Carlo; Frigo, Maura; Cavaletti, Guido

Elsevier BV

Medicine; Immunology and Microbiology; Neuroscience

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