Transcellular transmission and molecular heterogeneity of aggregation-prone proteins in neurodegenerative diseases
Molecules and Cells, ISSN: 1016-8478, Vol: 47, Issue: 8, Page: 100089
2024
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Transcellular transmission and molecular heterogeneity of aggregation-prone proteins in neurodegenerative diseases.
Mol Cells. 2024 Jul 4;:100089. Authors: Lee E, Park H, Kim S PubMed: 38971320 Submit Comment
Review Description
The accumulation of aggregation-prone proteins in a specific neuronal population is a common feature of neurodegenerative diseases, which is correlated with the development of pathological lesions in diseased brains. The formation and progression of pathological protein aggregates in susceptible neurons induce cellular dysfunction, resulting in progressive degeneration. Moreover, recent evidence supports the notion that the cell-to-cell transmission of pathological protein aggregates may be involved in the onset and progression of many neurodegenerative diseases. Indeed, several studies have identified different pathological aggregate strains. Although how these different aggregate strains form remains unclear, a variety of biomolecular compositions or cross-seeding events promoted by the presence of other protein aggregates in the cellular environment may affect the formation of different strains of pathological aggregates, which in turn can influence complex pathologies in diseased brains. In this review, we summarize the recent results regarding cell-to-cell transmission and the molecular heterogeneity of pathological aggregate strains, raising key questions for future research directions.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1016847824001146; http://dx.doi.org/10.1016/j.mocell.2024.100089; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85198507768&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/38971320; https://linkinghub.elsevier.com/retrieve/pii/S1016847824001146
Elsevier BV
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