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C3-induced release of neurotrophic factors from Schwann cells – potential mechanism behind its regeneration promoting activity

Neurochemistry International, ISSN: 0197-0186, Vol: 90, Page: 232-245
2015
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Article Description

Previous studies revealed a peripheral nerve regeneration (PNR) 1 promoting activity of Clostridium botulinum C3 2 exoenzyme or a 26 mer C-terminal peptide fragment covering amino acids 156–181 (C3 156−181 ), 3 when delivered as one-time injection at the lesion site. The current study was performed to 1) investigate if prolonged availability of C3 and C3 156−181 at the lesion site can further enhance PNR in vivo and to 2) elucidate effects of C3 and C3 156−181 on Schwann cells (SCs) 4 in vitro.

Bibliographic Details

Rohrbeck, Astrid; Stahl, Frank; Höltje, Markus; Hettwer, Timo; Lindner, Patrick; Hagemann, Sandra; Pich, Andreas; Haastert-Talini, Kirsten

Elsevier BV

Neuroscience; Biochemistry, Genetics and Molecular Biology

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