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Effects of electrical stimulation of the rat vestibular labyrinth on c-Fos expression in the hippocampus

Neuroscience Letters, ISSN: 0304-3940, Vol: 677, Page: 60-64
2018
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SYSTEM RESEARCH : Findings on Neuroscience Reported by Investigators at University of Auckland (Effects of electrical stimulation of the rat vestibular labyrinth on...

Findings on Neuroscience Reported by Investigators at University of Auckland (Effects of electrical stimulation of the rat vestibular labyrinth on c-Fos expression in the hippocampus)

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Several studies have demonstrated that electrical activation of the peripheral vestibular system can evoke field potential, multi-unit neuronal activity and acetylcholine release in the hippocampus (HPC). However, no study to date has employed the immediate early gene protein, c-Fos, to investigate the distribution of activation of cells in the HPC following electrical stimulation of the vestibular system. We found that vestibular stimulation increased the number of animals expressing c-Fos in the dorsal HPC compared to sham control rats (P ≤ 0.02), but not in the ventral HPC. c-Fos was also expressed in an increased number of animals in the dorsal dentate gyrus (DG) compared to sham control rats (P ≤ 0.0001), and to a lesser extent in the ventral DG (P ≤ 0.006). The results of this study show that activation of the vestibular system results in a differential increase in the expression of c-Fos across different regions of the HPC.

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