Improvement of non-motor and motor behavioral alterations associated with Parkinson-like disease in Drosophila melanogaster : Comparative effects of treatments with hesperidin and L-dopa
NeuroToxicology, ISSN: 0161-813X, Vol: 89, Page: 174-183
2022
- 12Citations
- 28Captures
- 1Mentions
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Metrics Details
- Citations12
- Citation Indexes12
- 12
- CrossRef7
- Captures28
- Readers28
- 28
- Mentions1
- News Mentions1
- News1
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Article Description
Non-motor alterations such as anxiety and memory deficit may represent early indications of Parkinson’s disease (PD), and therapeutic strategies that reduce non-motor alterations are promising alternatives for the treatment. Therefore, the search for natural compounds that act on motor and non-motor complications is highly relevant. In this sense, we demonstrated the role of hesperidin (Hsd) as a citrus flavonoid and its pharmacological properties as an antioxidant and neuroprotective agent. Our objective was to evaluate Hsd in developing motor and non-motor alterations in a Drosophila melanogaster model of Parkinson-like disease induced by iron (Fe) exposure. The flies were divided into six groups: control, Hsd (10 µM), L -dopa (positive control, 1 mM), Fe (1 mM), Fe + Hsd, and Fe + L -dopa. Motor coordination tests, memory assessment through aversive phototaxy, and anxiety-like behaviors characterized in flies, such as grooming and aggressiveness, were performed. The Hsd attenuated motor and non-motor alterations, such as motor coordination, memory deficits and anxiety-like behaviors, attenuated monoaminergic deficits, and lowered Fe levels in the head of flies. In addition, Hsd prolonged the life of the flies, thereby standing out from the L -dopa-treated group. Thus, Hsd can protect the dopaminergic system from insults caused by Fe, preventing non-motor alterations in PD; Hsd also reduced Fe levels in the flies’ heads, suggesting that iron chelation may represent an important mechanism of action, in addition to its antioxidant action.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0161813X22000237; http://dx.doi.org/10.1016/j.neuro.2022.02.004; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85124520742&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/35167856; https://linkinghub.elsevier.com/retrieve/pii/S0161813X22000237; https://dx.doi.org/10.1016/j.neuro.2022.02.004
Elsevier BV
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