A novel immune modulator IM33 mediates a glia-gut-neuronal axis that controls lifespan
Neuron, ISSN: 0896-6273, Vol: 111, Issue: 20, Page: 3244-3254.e8
2023
- 4Citations
- 32Captures
- 3Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations4
- Citation Indexes4
- CrossRef3
- Captures32
- Readers32
- 32
- Mentions3
- News Mentions2
- News2
- References1
- Wikipedia1
Most Recent News
Има имунна молекула, регулираща стареенето и продължителността на живота на жив организъм
Експресията на IM33 в мозъка на муха. Синьо: DAPI, флуоресцентно багрило, което има силен афинитет към ДНК и обозначава ядрото на всички клетки. Маджента: IM33
Article Description
Aging is a complex process involving various systems and behavioral changes. Altered immune regulation, dysbiosis, oxidative stress, and sleep decline are common features of aging, but their interconnection is poorly understood. Using Drosophila, we discover that IM33, a novel immune modulator, and its mammalian homolog, secretory leukocyte protease inhibitor (SLPI), are upregulated in old flies and old mice, respectively. Knockdown of IM33 in glia elevates the gut reactive oxygen species (ROS) level and alters gut microbiota composition, including increased Lactiplantibacillus plantarum abundance, leading to a shortened lifespan. Additionally, dysbiosis induces sleep fragmentation through the activation of insulin-producing cells in the brain, which is mediated by the binding of Lactiplantibacillus plantarum -produced DAP-type peptidoglycan to the peptidoglycan recognition protein LE (PGRP-LE) receptor. Therefore, IM33 plays a role in the glia-microbiota-neuronal axis, connecting neuroinflammation, dysbiosis, and sleep decline during aging. Identifying molecular mediators of these processes could lead to the development of innovative strategies for extending lifespan.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0896627323005433; http://dx.doi.org/10.1016/j.neuron.2023.07.010; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85173716359&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/37582366; https://linkinghub.elsevier.com/retrieve/pii/S0896627323005433; https://dx.doi.org/10.1016/j.neuron.2023.07.010
Elsevier BV
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