PlumX Metrics
Embed PlumX Metrics

Activation of group III metabotropic glutamate receptors presynaptically reduces both GABAergic and glutamatergic transmission in the rat globus pallidus

Neuroscience, ISSN: 0306-4522, Vol: 122, Issue: 3, Page: 727-737
2003
  • 61
    Citations
  • 0
    Usage
  • 29
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

To investigate the role of group III metabotropic glutamate receptors (mGluRs) in the globus pallidus (GP), whole-cell recordings were performed using rat brain slice preparations. Application of the group III mGluRs specific agonist l (+)-2-amino-4-phosphonobutyric acid ( l -AP4) suppressed the amplitude of striatal stimulation-induced IPSCs and internal capsule stimulation-induced EPSCs in most of the GP neurons that were capable of generating repetitive firing without spike accommodation. The suppression of IPSCs and EPSCs was accompanied by an increase in the paired-pulse ratio. The l -AP4 effects were antagonized by ( R, S )-alpha-cyclopropyl-4-phosphophenylglycine, a blocker for group II/III mGluRs. l -AP4 reduced the frequency of mIPSCs and mEPSCs without changing their amplitude distribution. l -AP4 failed to change iontophoretic glutamate induced responses. These results suggest that the subthalamo-pallidal glutamatergic input might homo- and hetero-synaptically control GABAergic and glutamatergic transmission in the GP.

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know