Glutamate-induced deregulation of calcium homeostasis and mitochondrial dysfunction in mammalian central neurones
Progress in Biophysics and Molecular Biology, ISSN: 0079-6107, Vol: 86, Issue: 2, Page: 279-351
2004
- 153Citations
- 63Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations153
- Citation Indexes153
- 153
- CrossRef108
- Captures63
- Readers63
- 63
Review Description
Delayed neuronal death following prolonged (10–15 min) stimulation of Glu receptors is known to depend on sustained elevation of cytosolic Ca 2+ concentration ([Ca 2+ ] i ) which may persist far beyond the termination of Glu exposure. Mitochondrial depolarization (MD) plays a central role in this Ca 2+ deregulation: it inhibits the uniporter-mediated Ca 2+ uptake and reverses ATP synthetase which enhances greatly ATP consumption during Glu exposure. MD-induced inhibition of Ca 2+ uptake in the face of continued Ca 2+ influx through Glu-activated channels leads to a secondary increase of [Ca 2+ ] i which, in its turn, enhances MD and thus [Ca 2+ ] i. Antioxidants fail to suppress this pathological regenerative process which indicates that reactive oxygen species are not involved in its development. In mature nerve cells (>11 DIV), the post-glutamate [Ca 2+ ] i plateau associated with profound MD usually appears after 10–15 min Glu (100 μM) exposure. In contrast, in young cells (<9 DIV) delayed Ca 2+ deregulation (DCD) occurs only after 30–60 min Glu exposure. This difference is apparently determined by a dramatic increase in the susceptibility of mitochondia to Ca 2+ overload during nerve cells maturation. The exact mechanisms of Glu-induced profound MD and its coupling with the impairment of Ca 2+ extrusion following toxic Glu challenge is not clarified yet. Their elucidation demands a study of dynamic changes in local concentrations of ATP, Ca 2+, H +, Na + and protein kinase C using novel methodological approaches.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0079610703000828; http://dx.doi.org/10.1016/j.pbiomolbio.2003.10.002; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=2342636810&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/15288761; https://linkinghub.elsevier.com/retrieve/pii/S0079610703000828; https://dx.doi.org/10.1016/j.pbiomolbio.2003.10.002
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know