Four new compounds with cytotoxic and neuroprotective activity from Notopterygium incisum
Phytochemistry Letters, ISSN: 1874-3900, Vol: 49, Page: 138-144
2022
- 6Citations
- 5Captures
- 1Mentions
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Most Recent News
Researchers at Chinese Academy of Sciences Report New Data on Phytochemistry (Four New Compounds With Cytotoxic and Neuroprotective Activity From Notopterygium Incisum)
2023 FEB 08 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Daily -- Current study results on Chemistry - Phytochemistry have
Article Description
Phytochemical research on an extract of Notopterygium incisum yielded twenty-four compounds ( 1 – 24 ), including four new compounds 7, 10, 13 and 17. The structures of new compounds were elucidated by spectroscopic analysis, and the absolute configuration of 5 were assigned via Mosher's method. In addition, compounds 2, 9, 19 and 24 were analyzed by single crystal X-ray analysis for the first time. The new compound 7 exhibited remarkable cytotoxic activity against the human pancreatic cancer cell lines PANC-1, CAPAN-2, CFPAC-1, and SW1990 with IC 50 values of 6.25 ± 0.54, 7.74 ± 1.12, 6.68 ± 1.11, and 5.35 ± 0.33 μM, respectively. The primary mechanistic study indicated that 7 caused cell death probably due to induced defects in the mitotic process. Moreover, compounds 2 and 7 - 9 effectively protected against H 2 O 2 -induced neurotoxicity in the SH-SY5Y cells, and 1, 3, 6, 10, 11, 16 and 19 exhibited strong DPPH scavenging ability.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S187439002200060X; http://dx.doi.org/10.1016/j.phytol.2022.03.007; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85127816405&origin=inward; https://linkinghub.elsevier.com/retrieve/pii/S187439002200060X; https://dx.doi.org/10.1016/j.phytol.2022.03.007
Elsevier BV
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