Volumetric brain assessment of long-term head and neck cancer survivors
Radiotherapy and Oncology, ISSN: 0167-8140, Vol: 191, Page: 110068
2024
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Most Recent News
Researchers from University of Alabama Birmingham Describe Findings in Head and Neck Cancer (Volumetric Brain Assessment of Long-term Head and Neck Cancer Survivors)
2024 MAR 22 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Daily -- Current study results on Oncology - Head and Neck Cancer
Article Description
Radiation therapy (RT) for locally advanced head and neck cancer (HNC) often exposes subcortical brain structures to radiation. We performed this study to assess region-specific brain volumetrics in a population of long term HNC survivors. Forty HNC survivors were enrolled at a mean of 6.4 years from completion of RT. Patients underwent a research MRI protocol that included a 3D T1- weighted whole-brain scan on a 3 Tesla MRI scanner. Voxel based morphometry was performed using the Computational Anatomy Toolbox with the Neuromorphometrics atlas. Healthy controls from the Human Connectome Project were used as a comparison cohort. Study participants also completed a comprehensive neurocognitive assessment. The final study cohort consisted of 38 participants after excluding 2 participants due to image quality. HNC survivors displayed widespread reduction in gray matter (GM) brain region volumes that included bilateral medial frontal cortex, temporal lobe, hippocampus, supplemental motor area, and cerebellum. Greater radiation exposure was associated with reduced GM volume in the left ventral diencephalon (r = -0.512, p = 0.003). Associations between cognition and regional GM volumes were identified for motor coordination and bilateral cerebellum (left, r = 0.444, p = 0.009; right, r = 0.372, p = 0.030), confrontation naming and left amygdala (r = 0.382, p = 0.026), verbal memory and bilateral thalamus (left, r = 0.435, p = 0.010; right, r = 0.424, p = 0.012), right amygdala (r = 0.339, p = 0.050), and right putamen (r = 0.364, p = 0.034). Reductions in GM were observed within this cohort of primarily non-nasopharyngeal HNC survivors as compared to a control sample. GM volumes were associated with performance in multiple cognitive domains. Results of this exploratory study support the need for investigation of anatomic brain changes as an important translational corollary to cognitive problems among HNC survivors.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0167814023093751; http://dx.doi.org/10.1016/j.radonc.2023.110068; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85181673218&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/38142935; https://linkinghub.elsevier.com/retrieve/pii/S0167814023093751; https://dx.doi.org/10.1016/j.radonc.2023.110068
Elsevier BV
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