Effects of per- and polyfluorinated compounds on adult rat testicular cells following in vitro exposure
Reproductive Toxicology, ISSN: 0890-6238, Vol: 33, Issue: 4, Page: 531-537
2012
- 24Citations
- 23Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations24
- Citation Indexes18
- 18
- CrossRef13
- Policy Citations6
- Policy Citation6
- Captures23
- Readers23
- 23
Article Description
Testicular toxicity is observed following exposure of rats to per- and polyfluorinated compounds (PFCs). Such compounds were also shown to induce oxidative stress and changes in ABC efflux transporters e.g. P-gp, implying two mechanisms which may contribute to testicular toxicity. We studied the toxicity of four PFCs (PFOA, PFNA, 8:2 FTOH and 6:2 FTOH) on primary rat testicular cells. DNA damage was studied by the comet assay including Fpg enzyme treatment to detect oxidative lesions. The levels of the ABC efflux transporters Bcrp1, Oat2 and P-gp were studied by real-time RT-PCR or flow cytometry. A PFNA associated increase in DNA SSBs was attributed to a subpopulation of moderately damaged cells possibly associated with cytotoxicity. No significant increase in oxidative DNA damage was measured for any of the PFCs. Expression levels of ABC efflux transporters suggest that PFCs may increase expression levels of the P-gp protein and the Oat2 gene.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S089062381100116X; http://dx.doi.org/10.1016/j.reprotox.2011.04.001; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84861530543&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/21530637; https://linkinghub.elsevier.com/retrieve/pii/S089062381100116X; https://dx.doi.org/10.1016/j.reprotox.2011.04.001
Elsevier BV
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