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Targeting micro-environmental pathways by PROTACs as a therapeutic strategy

Seminars in Cancer Biology, ISSN: 1044-579X, Vol: 86, Issue: Pt 2, Page: 269-279
2022
  • 11
    Citations
  • 0
    Usage
  • 30
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  • 1
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  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

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Most Recent News

Studies Conducted at Beth Israel Deaconess Medical Center on Cancer Recently Reported (Targeting Micro-environmental Pathways By Protacs As A)

2023 JAN 02 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Oncology Daily -- Investigators publish new report on Cancer. According to news

Review Description

Tumor microenvironment (TME) composes of multiple cell types and non-cellular components, which supports the proliferation, metastasis and immune surveillance evasion of tumor cells, as well as accounts for the resistance to therapies. Therefore, therapeutic strategies using small molecule inhibitors (SMIs) and antibodies to block potential targets in TME are practical for cancer treatment. Targeted protein degradation using PROteolysis-TArgeting Chimera (PROTAC) technic has several advantages over traditional SMIs and antibodies, including overcoming drug resistance. Thus many PROTACs are currently under development for cancer treatment. In this review, we summarize the recent progress of PROTAC development that target TME pathways and propose the potential direction of future PROTAC technique to advance as novel cancer treatment options.

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