Inhibitory effects of tangeretin and trans-ethyl caffeate on the HMG-CoA reductase activity: Potential agents for reducing cholesterol levels
Saudi Journal of Biological Sciences, ISSN: 1319-562X, Vol: 27, Issue: 8, Page: 1947-1960
2020
- 18Citations
- 59Captures
- 1Mentions
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Metrics Details
- Citations18
- Citation Indexes18
- 18
- CrossRef5
- Captures59
- Readers59
- 59
- Mentions1
- News Mentions1
- News1
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Effect of Ethanol Extract from Kersen Leaves (Muntingia calabura L.) on Changes in Blood Factors Total Cholesterol, Triglycerides, LDL and HDL in Hyperlipidemia Mice
Tridiganita Intan Solikhah1,2*, Gahastanira Permata Solikhah3 1Division of Veterinary Clinic, Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Indonesia. 2Faculty of Health, Medicine,
Article Description
One of the pathways to reduce cholesterol production in the liver is through the inhibition of HMG-Coa reductase (HMGCR) by current drugs, statins. However, these have side effects if consumed in prolonged periods. Tangeretin and trans-ethyl caffeate as alternative drugs in reducing hypercholesterolemia and preventing atherosclerosis have never been reported. Their effects on inhibiting HMGCR activity were investigated through enzymatic method ( in vitro and in vivo ). The toxicity property was analyzed on the Serum Glutamate Oxalate Transaminase (SGOT)/Serum Glutamate Piruvate Transaminase (SGPT) levels and rat liver histology. The results showed that both compounds inhibited HMGCR activity significantly compare to the control simvastatin ( p < 0.05). Tangeretin which showed very good activity in inhibiting HMGCR (83.8 of % inhibition, equal to simvastatin) was selected and used for anti-hypercholesterolemia in vivo assessment. Furthermore, tangeretin was shown to effectively reduced Total Cholesterol (TC) and Low Density Lipoprotein (LDL), and increased High Density Lipoprotein (HDL) levels significantly compared to the simvastatin group ( p < 0.05). Tangeretin group was also proven to inhibit HMGCR rat liver activity significantly compare to the control simvastatin ( p < 0.05). The toxicity study on the SGOT/SGPT levels and liver histology revealed that there were no side effects after administration by tangeretin. Results found that both tangeretin and trans-ethyl caffeate are potent candidates as anti-hypercholesterolemia agent in vitro. In addition, tangeretin was also shown to be safe and suitable as an alternative treatment for controlling hypercholesterolemia in vivo as well as have potency for preventing atherosclerosis.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1319562X20302503; http://dx.doi.org/10.1016/j.sjbs.2020.06.010; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85087033452&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/32714018; https://linkinghub.elsevier.com/retrieve/pii/S1319562X20302503; https://dx.doi.org/10.1016/j.sjbs.2020.06.010
Elsevier BV
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