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Immunosurveillance of Malignant Cells with Complex Karyotypes

Trends in Cell Biology, ISSN: 0962-8924, Vol: 27, Issue: 12, Page: 880-884
2017
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Article Description

A wide array of cell-intrinsic surveillance mechanisms maintains the homeostasis of dividing cells and the integrity of the genome. Accumulating evidence also supports a role for cell-extrinsic mechanisms. Among them, the immune system, together with cell-autonomous checkpoint processes, eliminates cells that harbor unbalanced karyotypes generated by mitotic defects.

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