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Caspase 2 and p53 Reunited in Tumor Control

Trends in Cell Biology, ISSN: 0962-8924, Vol: 30, Issue: 12, Page: 917-918
2020
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Article Description

Recent findings ( Tsabar et al. ) demonstrate that human cancer cells that evade the cell cycle blockage normally imposed by DNA damage experience sustained p53 signaling upon MDM2 degradation by caspase 2. Such a response may be connected to the delivery of immunostimulatory signals to ensure the elimination of genetically instable cancer cells.

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